2023
Park I, Kim K, Kim J, Kim A, Bae S, Jung M, Choi J, Mishra PK, Kim T, Kwak C, Kang M, Yoo C, Mun JY, Liu K, Lee K#, Kim J#, Suh JM#, Rhee H#. Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis. Nature Chemical Biology. 2023. doi: 10.1038/s41589-023-01452-w
Park A, Kim K, Park I, Lee SH, Park K, Jung M, Li X, Sleiman MB, Lee SJ, Kim D, Kim J, Lim D, Woo E, Lee EW, Han BS, Oh K, Lee SC, Auwerx J, Mun JY, Rhee H, Kim WK#, Bae K#, Suh JM#. Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice. Nature Communications. 2023. doi: 10.1038/s41467-023-39106-z
Kim H, Shin Y, Kim HN, Yang K, Ryu T, Kim K, Choi SE, Kim MJ, Woo C, Chung KPS, Hong SH, Shin H, Suh JM, Jung Y, Hwang G, Kim W, Kim S, Eun HS, Seong JK#, Jeong WI#. xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity. Cell Reports. 2023. doi: 10.1016/j.celrep.2023.112636
Choi JB, Seol D, Do H, Yang H, Kim T, Byun YG, Park J, Choi J, Hong SP, Chung W, Suh JM, Koh GY, Lee BH, Wee G#, Han Y#. Fasudil alleviates the vascular endothelial dysfunction and several phenotypes of Fabry disease. Molecular Therapy. 2023. doi: 10.1016/j.ymthe.2023.02.003
2022
Kim J, Park K, Choi S, Ko UH, Lim D, Suh JM#, Shin JH#. Ceiling culture chip reveals dynamic lipid droplet transport during adipocyte dedifferentiation via actin remodeling. Lab on a Chip. 2022. doi: 10.1039/d2lc00428c
Choi J, Oh TG, Jung H, Park K, Shin H, Jo T, Kang D, Chanda D, Hong S, Kim J, Hwang H, Ji M, Jung M, Shoji T, Matsushima A, Kim P, Mun JY, Paik M J, Cho SJ, Lee I K , Whitcomb D, Greer P, Blobner B, Goodarzi M, Pandol S, Rotter J, Fan W, Bapat S, Zheng Y, Leddle C, Yu R, Atkins A, Downes M, Yoshihara E#, Evans R#, Suh JM#. Estrogen-Related Receptor γ Maintains Pancreatic Acinar Cell Function and Identity by Regulating Cellular Metabolism. Gastroenterology. 2022. doi: 10.1053/j.gastro.2022.04.013.
2021
Kim KE, Park I, Kim J, Kang MG, Choi WG, Shin H, Kim JS#, Rhee HW#, Suh JM#. Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice. Nat Commun. 2021 Sep 1;12(1):5204. doi: 10.1038/s41467-021-25546-y.
Yeom E, Shin H, Yoo W, Jun E, Kim S, Hong SH, Kwon DW, Ryu TH, Suh JM#, Kim SC#, Lee KS#, Yu K#. Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain. Nat Cell Biol. 2021 Feb;23(2):172-183.doi: 10.1038/s41556-020-00628-z. Epub 2021 Feb 8.
Bae EJ, Choi WG, Pagire HS, Pagire SH, Parameswaran S, Choi JH, Yoon J, Choi WI, Lee JH, Song JS, Bae MA, Kim M, Jeon JH, Lee IK, Kim H#, Ahn JH#. Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease. J Med Chem. 2021 Jan 28;64(2):1037-1053.doi: 10.1021/acs.jmedchem.0c01560. Epub 2021 Jan 8.
2020
Shong KE, Oh CM, Namkung J, Park S#, Kim H#. Serotonin Regulates De Novo Lipogenesis in Adipose Tissues Through Serotonin Receptor 2A. Endocrinol Metab (Seoul). 2020 Jun;35(2):470-479. doi: 10.3803/EnM.2020.35.2.470. Epub 2020 Jun 24.
Moon JH, Kim H, Kim H, Park J, Choi W, Choi W, Hong HJ, Ro HJ, Jun S, Choi SH, Banerjee RR, Shong M, Cho NH, Kim SK, German MS#, Jang HC#, Kim H#. Lactation improves pancreatic β cell mass and function through serotonin production. Sci Transl Med. 2020 Apr 29;12(541). pii: eaay0455. doi: 10.1126/scitranslmed.aay0455.
Kim M, Hwang I, Pagire HS, Pagire SH, Choi W, Choi WG, Yoon J, Lee WM, Song JS, Yoo EK, Lee SM, Kim MJ, Bae MA, Kim D, Lee H, Lee EY, Jeon JH, Lee IK, Kim H#, Ahn JH#. Design, Synthesis, and Biological Evaluation of New Peripheral 5HT2A Antagonists for Nonalcoholic Fatty Liver Disease. J Med Chem. 2020 Apr 14. doi: 10.1021/acs.jmedchem.0c00002.
Choi W, Moon JH, Kim H. Serotonergic regulation of energy metabolism in peripheral tissues. J. Endocrinol.
2020 Apr;245(1):R1-R10. doi: 10.1530/JOE-19-0546.
2019
Kim H, Yoon ΒH, Oh CM, Lee J, Lee K, Song H, Kim E, Yi K, Kim MY, Kim H, Kim YK, Seo EH, Heo H, Kim HJ, Lee J, Suh JM, Koo SH, Seong JK, Kim S, Ju YS, Shong M, Kim M#, Kim H#. PRMT1 is Required for the Maintenance of Mature β Cell Identity. Diabetes. 2019 Dec 17. pii: db190685. doi: 10.2337/db19-0685.
Moon JH, Kim YG, Kim K, Osonoi S, Wang S, Saunders DC, Wang J, Yang K, Kim H, Lee J, Jeong JS, Banerjee RR, Kim SK, Wu Y, Mizukami H, Powers AC, German MS#, Kim H#. Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation. Diabetes. 2019 Dec 5. pii: db190546. doi: 10.2337/db19-0546.
Lee K, Kim H, Lee J, Oh CM, Song H, Kim H, Koo SH, Lee J, Lim A, Kim H. Essential Role of Protein Arginine Methyltransferase 1 in Pancreas Development by Regulating Protein Stability of Neurogenin 3. Diabetes Metab J. 2019 Apr 8. doi: 10.4093/dmj.2018.0232.
2018
Kim H, Kim YG, Choi W, Moon JH, Hwang I, Kim K, Yadav VK, Karsenty G, Jeong JS#, Kim H#. Generation of a highly efficient and tissue-specific tryptophan hydroxylase 1 knockout mouse model. Sci Rep. 2018 Dec 5;17642 (# cocorresponding author)
Choi W, Namkung J, Hwang I, Kim H, Lim A, Park HJ, Lee HW, Han KH, Park S, Jeong JS, Bang G, Kim YH, Yadav V, Karsenty G, Ju JS, Choi C, Suh JM, Park JY, Park S, Kim H. Serotonin signals through a gut-liver axis to regulate hepatic steatosis. Nat Commun. 2018 Nov 9:4824
Namkung J, Shong KE, Kim H, Oh CM, Park S, Kim H. Inhibition of Serotonin Synthesis Induces Negative Hepatic Lipid Balance. Diabetes Metab J. 2018 Jun;42(3):233-243
Kim BH, Jung HW, Seo SH, Shin H, Kwon J#, Suh JM#. Synergistic actions of FGF2 and bone marrow transplantation mitigate radiation-induced intestinal injury. Cell Death Dis. 2018 Mar 7;9(3):383 (# cocorresponding author)
Kim H, Kim H, Kim K, German MS, Kim H. Ectopic serotonin production in β-cell specific transgenic mice. Biochem Biophys Res Commun. 2018 Jan 8;495(2):1986-1991.
2017
Kim YG, Moon JH, Kim K, Kim H, Kim J, Jeong JS, Lee J, Kang S, Park JS, Kim H#. β-cell serotonin production is associated with female sex, old age, and diabetes-free condition.Biochem Biophys Res Commun. 2017 Nov 25;493(3):1197-120 (# cocorresponding author)
2016
Kim Y, Kim H, Ko UH, Oh Y, Lim A, Sohn JW, Shin JH, Kim H#, Han YM#. Islet-like organoids derived from human pluripotent stem cells efficiently function in the glucose responsiveness in vitro and in vivo. Sci Rep. 2016 Oct 12;6:35145. (# cocorresponding author)
Oh CM, Park S, Kim H. Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity. Diabetes Metab J. 2016 Apr;40(2):89-98.
2015
Namkung J, Kim H#, Park S#. Peripheral Serotonin: a New Player in Systemic Energy Homeostasis. Mol Cells. 2015 Dec 31;38(12):1023-8. ( # cocorresponding author)
Park H, Oh CM, Park J, Park H, Cui S, Kim H, Namkung J, Park S, Pak HN, Lee MH, Kim H#, Joung B#. Deletion of the serotonin receptor type 3A in mice leads to sudden cardiac death during pregnancy. Circ J. 2015;79(8):1807-15. (# cocorresponding author)
Oh CM, Namkung J, Go Y, Shong KE, Kim K, Kim H, Park BY, Lee HW, Jeon YH, Song J, Shong M, Yadav VK, Karsenty G, Kajimura S, Lee IK#, Park S#, Kim H#. Regulation of systemic energy homeostasis by serotonin in adipose tissues. Nat Commun. 2015 Apr 13;6:6794. doi: 10.1038/ncomms7794 . (# cocorresponding author)
Kim K, Oh CM, Ohara-Imaizumi M, Park ,S Namkung J, Yadav VK, Tamarina NA, Roe MW, Philipson LH, Karsenty H, Nagamatsu S, German MS, Kim H. Functional role of serotoninin insulin secretion in a dietinduced insulin-resistant state. Endocrinology. 2015 Feb;156(2):444-452